The global prefilled syringes market size is estimated to grow from USD 3.02 billion in 2024 to USD 4.97 billion by 2035, representing a CAGR of 4.6% during the forecast period till 2035.

With the increasing population, the incidence rates of various chronic diseases, such as diabetes, autoimmune disorders, cardiovascular disorders and oncological disorders, are witnessing an upward trend. Various conditions require regular and long-term medications, driving a demand for reliable drug delivery systems. Further, non-adherence to prescribed medication regimen is one of the major factors that not only causes negative implications on the patient’s health, but also adds to the overall pharmaceutical industry’s burden. According to an article published by Contract Pharma in April 2022, non-adherence to prescribed medicines is estimated to cost more than USD 250 billion annually to the drug developers.

As a result, drug delivery devices have undergone significant advancements in the recent years, providing various options to administer a myriad of drugs (catering to different indications) with accuracy and ease. Among the various innovations, prefilled syringes have gained prominence in the healthcare domain as they offer various advantages, including simplified drug administration process (as there is no need for manual filling of drugs), decreased dosing errors (as the syringe is preloaded with precise medication), reduced risk of contamination (as the prefilled syringes are sealed) and enhanced patient adherence (as they can be readily administered in home settings).

Notably, the prefilled syringes domain has witnessed some innovations, that have been mentioned below:

Needle Safety Features: Needle safety mechanisms such as shielded needles or retractable needles have been incorporated to prevent needle stick injuries and improve safety of the devices.

Integration of Autoinjectors: Autoinjectors have been incorporated with prefilled syringes to offer user friendly and automated drug administration.

Dual Chamber Prefilled Syringes: These syringes allow mixing to two different drugs, such as lyophilized drugs and diluents, just prior to their administration

Flush Syringes: These syringes are designed for flushing vascular access devices, such as catheters and intravenous lines


Prefilled Syringes Market Landscape

The current market landscape features the presence of close to 125 prefilled syringes that are currently available / under development for the delivery of different types of medications. The prefilled syringes market is highly fragmented, featuring the presence of established companies, as well as emerging start-ups. Majority of the companies engaged in this domain are headquartered in Asia-Pacific; of these, over 40% are based India.

Notably, players engaged in this domain are shifting their focus towards the development of plastic prefilled syringes; this can be attributed to the various advantages offered by these syringes, including breakage resistance, light-weight, economical manufacturing and decreased risk of contamination. Further, over 5% of the syringes are available in both glass as well as plastic barrel format.

Most of the prefilled syringes are being developed with luer needle system; these syringes have  threaded rims provides a unique locking system, thereby, preventing the needle from being pulled off by the syringe body inadvertently. Further, prefilled syringes are developed in different volume formats, considering the preferences and needs of the customers.


Innovative Pairing: Prefilled Syringe combination products shaping healthcare

During our research, we identified over 120 drugs that have received approval to be used in combination with prefilled syringes, during the period 2013-2023 (till October) and over 50 drugs that are currently being developed in combination with prefilled syringes.

Majority of the drugs being evaluated in late stages of development (phase I/II or phase III) are targeting autoimmune disorders. It is worth mentioning that subcutaneous route is the most preferred route for drug administration by these combination products due to reduced pain and discomfort, convenient self-administration and stable drug absorption.

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