Kiko Garcia

Kiko Garcia added blog Health
2025-05-07 09:11:36 -

PacBio HiFi Sequencing
PacBio sequencing technology has evolved to a different type of long read, known as highly accurate long reads, or HiFi reads. PacBio, the only sequencing technology to offer HiFi reads, is 99.9% accurate, comparable to short reads and Sanger sequencing. With HiFi reads, you no longer need to sacrifice long read lengths for high-precision sequencing to solve the toughest...

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Kiko Garcia added blog Health
2025-05-07 09:07:48 -

Fusion Transcript Sequencing
Overview Fusion genes are caused by chromosomal aberrations such as translocations, duplications, inversions or small interstitial deletions. At the transcript level, fusion genes may not only reflect underlying genomic rearrangements, but may also arise as a result of aberrant transcription or trans-splicing events. Fusion genes are a major cause of cancer, accounting for approximately 20% of...

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Kiko Garcia added blog Health
2025-03-26 07:32:33 -

The Applications of DAP-seq Technology
Transcription factors (TFs) binding to specific locations in the genome influence dynamic changes in transcription levels. Disruption of TF binding sites (TFBS) correlates with phenotypic diversity and disease states, including agriculturally important adaptive traits and various diseases like cancer. Characterizing the genome-wide binding spectrum is crucial for exploring these...

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Kiko Garcia added blog Health
2025-03-26 07:27:22 -

Insights, Detecting Methods, and Medical Applications of DNA Methylation
What is DNA Methylation? DNA methylation is an important change in the genome that controls gene activity without changing the DNA sequence. This change involves adding a methyl group (CH₃) to the DNA, usually at certain points in the DNA sequence. DNA methyltransferases (DNMTs) catalyze this addition by transferring a methyl group from S-adenosylmethionine (SAM) to cytosine. As a fundamental...

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