Cailynn Johnson

Cailynn Johnson added blog Health
2025-05-27 07:41:41 -

CRISPR Activation (CRISPRa) screening
CRISPR Activation (CRISPRa) screening is a gain-of-function approach that enables targeted gene upregulation without modifying the DNA sequence. By using dCas9 fused to transcriptional activators, this method enhances endogenous gene expression, maintaining natural regulation and isoform diversity. CRISPRa screening is widely applied in functional genomics, drug discovery, and immune...

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Cailynn Johnson added blog Health
2025-05-27 07:40:25 -

Genome-wide CRISPR screening
Genome-wide CRISPR screening is a high-throughput approach that systematically explores gene function across the genome. Using sgRNA libraries, this method enables precise gene knockout, helping identify genes involved in drug resistance, cell viability, and disease progression. Compared to RNAi, CRISPR screening offers greater specificity and efficiency. Creative Biolabs provides comprehensive...

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Cailynn Johnson added blog Health
2025-05-27 07:39:23 -

CRISPR-based screening
CRISPR-based screening is a high-throughput approach that systematically explores gene function by modulating gene expression at the genomic level. This method is widely used in functional genomics, allowing researchers to identify genes involved in cell survival, drug resistance, immune modulation, and disease progression. Creative Biolabs offers customizable screening solutions, including...

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Cailynn Johnson added blog Health
2025-05-27 07:38:24 -

dCas9-KRAB overexpressing cell line
The dCas9-KRAB overexpressing cell line is a powerful tool for CRISPR interference (CRISPRi), enabling targeted gene silencing without altering the genome. By fusing nuclease-inactive Cas9 (dCas9) with the KRAB repression domain, this system suppresses transcription through epigenetic mechanisms. It is widely used for functional genomics, loss-of-function studies, and disease modeling.

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Cailynn Johnson added blog Health
2025-05-19 07:33:16 -

The Complement System: Key to Immune Defense and Regulation
The complement system is a critical component of the innate immune system, orchestrating a cascade of reactions to recognize and eliminate pathogens, while promoting inflammation. However, overactivation of the complement system can lead to various inflammatory and autoimmune diseases. The complement system comprises a group of serum proteins that can be activated through three...

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Cailynn Johnson added blog Health
2025-05-19 07:32:53 -

iPSC Technology: Paving the Way for Patient-Specific Neurological Therapies
Recent years have witnessed remarkable advancements in neuroscience, largely propelled by innovative technologies and interdisciplinary research. Among these, induced pluripotent stem cells (iPSCs) have emerged as a transformative tool, enabling scientists to explore the complexities of the human nervous system like never before. As the global scientific community grapples with neurological...

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Cailynn Johnson added blog Health
2025-05-19 07:32:28 -

A New Era in Neurodegenerative Research: The Fusion of Human iPSCs and Transgenic Technology
Neurodegenerative diseases, characterized by the progressive loss of structure or function of neurons, including death of neurons, have become a significant global health concern. Conditions such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) not only diminish the quality of life for millions but also pose substantial economic burdens on...

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Cailynn Johnson added blog Health
2025-04-23 07:49:39 -

Advancements in Monkeypox Virus Research: Strategies for Effective Prevention and Treatment
The battle against emerging infectious diseases remains a critical frontier in the pursuit of global health security. Monkeypox, a rare but potentially severe viral infection, has recently come under the spotlight due to a surge in reported cases. Breakthroughs in monkeypox vaccine discovery, the development of mRNA vaccines, and innovative testing kits mark significant strides toward effective...

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Cailynn Johnson added blog Health
2025-04-23 07:47:34 -

From Mystery to Clarity: New Scientific Insights into Monkeypox
Monkeypox, a zoonotic viral infection, has recently garnered significant attention due to its rapid spread and the declaration of a global health emergency by the World Health Organization (WHO). As a biotech researcher, it is crucial to stay abreast of the latest developments in the field to understand the virus better and develop effective diagnostic and therapeutic strategies. Understanding...

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Cailynn Johnson added blog Health
2025-04-02 07:36:50 -

Join the Exclusive Webinar on Programmable Molecular Tools for Biology and Genome Editing
Are you at the forefront of gene therapy research? Eager to explore the latest advancements in programmable molecular tools? Then mark your calendar! Creative Biolabs, a leading provider of innovative solutions for gene therapy, is thrilled to announce an upcoming webinar focused on the revolutionary impact of programmable molecular tools on biology and gene editing. This insightful...

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Cailynn Johnson added blog Health
2025-03-22 06:02:55 -

Automation in Oligonucleotide Synthesis: Ensuring Consistency and Efficiency
Oligonucleotide synthesis is at the forefront of biotechnology, driving significant advancements in the development of next-generation therapeutics. These short DNA or RNA sequences are engineered to modulate gene expression, presenting novel solutions for treating a myriad of diseases, from genetic disorders to cancers. Innovations in Oligonucleotide Synthesis A key breakthrough in...

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Cailynn Johnson added blog Health
2025-03-22 06:00:59 -

Macrophages in Disease Treatment Research
Macrophages, integral components of the immune system, play a crucial role in maintaining homeostasis and combating infections. In recent years, researchers have uncovered the diverse applications of macrophages in disease treatment research. Atherosclerosis, a leading cause of cardiovascular diseases, involves the accumulation of plaques within arterial walls. Macrophages contribute...

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