CRISPR Activation (CRISPRa) screening is a gain-of-function approach that enables targeted gene upregulation without modifying the DNA sequence. By using dCas9 fused to transcriptional activators, this method enhances endogenous gene expression, maintaining natural regulation and isoform diversity. CRISPRa screening is widely applied in functional genomics, drug discovery, and immune modulation, helping identify genes involved in cell proliferation, differentiation, and therapeutic resistance.
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